HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 21948889, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 5-Aminoquinoline | HCID 11911 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Reactant | 3-[1-(5-Fluoro-2-methoxyphenyl)cycloprop-1-yl]-2-hydroxy-2-(trifluoromethyl)propanal | HCID 21948913 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 21948889 | HCID 21948889 | — |
Reaction Steps
Analogously to Example 37, 362 mg (2.5 mmol) of 5-aminoquinoline is reacted with 640 mg (2.09 mmol) of 3-[1-(5-fluoro-2-methoxyphenyl)cycloprop-1-yl]-2-hydroxy-2-(trifluoromethyl)propanal and 2.80 ml of concentrated acetic acid in 19 ml of toluene. After 6 hours, the chromatography is carried out on silica gel with hexane-ethyl acetate (0-100%), and 810 mg (90% of theory) of the product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07329753B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-1958ed226e9a4658835410c797fe20e4 |
| Source note | uspto-grants-2008_02 |