HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 69204021, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Reactant | 4-(4-Chloro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentanal | HCID 21948937 | — |
| Reactant | Methyl 5-aminoquinoline-2-carboxylate | HCID 45089604 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 69204021 | HCID 69204021 | — |
Reaction Steps
Analogously to Example 1, 250 mg (1.24 mmol) of 5-aminoquinoline-2-carboxylic acid methyl ester is reacted with 484 mg (1.49 mmol) of 4-(4-chloro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentanal and 1.40 ml of concentrated acetic acid in 20 ml of toluene. After chromatography on silica gel with hexane-ethyl acetate (0-100%), 500 mg (79% of theory) of the product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07329753B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-ed68b314895b4e3e87aded3a83328fb7 |
| Source note | uspto-grants-2008_02 |