HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 21948898, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 5-acetylamino-2-methyl-quinoline | HCID 6461206 | — |
| Reactant | HCID 21948907 | HCID 21948907 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | HCID 21948898 | HCID 21948898 | 18.4% |
Reaction Steps
Analogously to Example 76, 60 mg (1.46 mmol) of NaH (60%) and 244 mg (1.23 mmol) of 5-acetylamino-2-methyl-quinoline are reacted with 365 mg (0.81 mmol) of toluene-4-sulfonic acid-3-[1-(2,5-difluorophenyl)-cycloprop-1-yl]-2-(trifluoromethyl)-2-hydroxy-propyl ester. The crude product is treated analogously to Example 76 with 1 M sodium hydroxide solution. After chromatography on silica gel with hexane-ethyl acetate (30-50%), 67 mg of product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07329753B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-941e16a374c24b03a6509adf59883b5c |
| Source note | uspto-grants-2008_02 |