HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Quinolinamine, 2-methyl- → HCID 21948842, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Quinolinamine, 2-methyl- | HCID 148683 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Reactant | HCID 21948864 | HCID 21948864 | — |
| Product | HCID 21948842 | HCID 21948842 | — |
Reaction Steps
Analogously to Example 79, 200 mg (0.64 mmol) of 3-[1-(2-chloro-5-fluorophenyl)cyclobut-1-yl]-2-(trifluoromethyl)-propanal and 126 mg (0.80 mmol) of 5-amino-2-methylquinoline are reacted, and the isolated crude product is reduced with 102 mg (2.70 mmol) of NaBH4. After chromatography on silica gel with hexane-ethyl acetate, 165 mg of product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07329753B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-ba75efb8185c45658b8432919dfb07e6 |
| Source note | uspto-grants-2008_02 |