Diethyl Ether → 4-Iodo-1-tritylimidazole

Participants

Reaction Steps

To a solution of 4-iodoimidazole (1 eq) in DMF at room temperature was added triphenylmethyl chloride (1.2 eq). After stirring at room temperature for 24 h, the solution was poured into ice water and left stirring for 30 min. The solid was filtered and pumped on for several hours to yield the crude compound. Ethyl ether was added to the crude compound and the solution was filtered to yield 4-iodo-1-trityl-1H-imidazole (92%) as a white solid. MH+(437).

Provenance & Evidence