Hydrazine → HCID 23511436, compound

HRID 2055139Notes

Reaction equation

HRID 2055139 reaction equation
[CH3:1][N:2]([CH2:16][C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]=1)[CH2:3][CH2:4][N:5]1C(=O)C2C(=CC=CC=2)C1=O.NN>C(O)C>[CH3:1][N:2]([CH2:16][C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]=1)[CH2:3][CH2:4][NH2:5]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 23511438HCID 23511438, compound

Product 1

HCID 23511436HCID 23511436, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
65 °C

Procedure

To 2-[2-(methyl-quinolin-2-ylmethyl-amino)-ethyl]-isoindole-1,3-dione (1 eq) in ethanol was added hydrazine (2 eq). A reflux condenser was attached and the solution was heated 65° C. for 19 hours. The solution was then filtered, concentrated, and co-evaporated from toluene to yield N1-methyl-N1-quinolin-2-ylmethyl-ethane-1,2-diamine in quantitative yield as a dark oil. MH+(216)

Workup

  1. customA reflux condenser was attached
  2. filtrationThe solution was then filtered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-21117a9f197e4ddab1e00539de1c15f6
Source dataset
uspto-grants-2008_02
Patent number
US07332476B2

Reaction notes

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