Potassium Carbonate → Phthalimide

Participants

Reaction Steps

2-(4-[4-(6-chloro-pyridin-3-yl)-imidazol-1-yl]-butyl)-isoindole-1,3-dione. To a solution of 5-(1H-imidazol-4-yl)-2-chloro-pyridine (15.14 g, 84.1 mmoles) in DMF (336 ml) was added potassium carbonate (58.1 g, 420.6 mmoles) and N-(4-bromobutyl)phthalimide (59.3 g, 210.3 mmoles) at room temperature under dry conditions. The solution was left stirring at room temperature for 48 hours. The reaction was filtered and the resulting clear solution was dumped onto ice (1.5 L). The precipitate was filtered and rinsed with water (2×500 ml) and was pumped on for 1 hour. The material was than rinsed with diethyl ether (15×500 ml) and than was pumped on to yield 2-14-[4-(6-chloro-pyridin-3-yl)-imidazol-1-yl]-butyl)-isoindole-1,3-dione (25.16 g, 78%). MH+(381)

Provenance & Evidence