反应详情

A mixture of 1-formyl-cyclohexanecarboxylic acid methyl ester (1.23 g, 7.23 mmol), sodium acetate (1.0 g, 14.5 mmol) and O-benzylhydroxylamine hydrochloride (2.3 g, 14.5 mmol) were stirred in methanol (40 mL) for 18 h. The methanol was removed in vacuo and the residue partitioned between water and EtOAc. The aqueous phase was extracted with EtOAc (50 mL×2). The combined organic extracts were dried (MgSO4) and were evaporated in vacuo to provide the title compound as a clear colorless liquid (1.75 g, 88%). MH+276.

1. customThe methanol was removed in vacuo
2. customthe residue partitioned between water and EtOAc
3. extractionThe aqueous phase was extracted with EtOAc (50 mL×2)
4. dry with materialThe combined organic extracts were dried (MgSO4)
5. customwere evaporated in vacuo