HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2055184Generated: November 3, 2026
Hydrochloric Acid → 1-(Benzyloxyamino-methyl)-4,4-dimethyl-cyclohexanecarboxylic acid
https://huagongshe.com/reaction/2055184
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Benzenesulfonic acid, 4-(2-(4-(dimethylamino)phenyl)diazenyl)- | HCID 11037 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 1-(Benzyloxyimino-methyl)-4,4-dimethyl-cyclohexanecarboxylic acid | HCID 86606475 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(Benzyloxyamino-methyl)-4,4-dimethyl-cyclohexanecarboxylic acid | HCID 86606476 | — |
Reaction Steps
A solution of 1-(benzyloxyimino-methyl)-4,4-dimethyl-cyclohexanecarboxylic acid (1.47 g, 5.11 mmol) in methanol (100 mL) at 0° C. under a nitrogen atmosphere was added a trace amount of methyl orange. A solution of saturated methanolic HCl was added until a persistent red color was observed. Sodium cyanoborohydride (0.42 g, 6.68 mmol) was added portionwise alternately with methanolic HCl to maintain the red color. The reaction mixture was maintained at 0° C. for an additional 2 h and the volatiles were removed in vacuo. The product was used without further purification. MH+292.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07332485B2 |
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| Source dataset | uspto-grants-2008_02 |
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| ORD ID | ord-5b59443f58024a9cb66f3c3b4fd76fd1 |
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| Source note | uspto-grants-2008_02 |
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