N-Benzyloxy-N-{3-butyl-1-[N'-(4-trifluoromethyl-pyrimidin-2-yl)-hydrazinocarbonyl]-cyclobutylmethyl}-formamide → N-{3-Butyl-1-[N'-(4-trifluoromethyl-pyrimidin-2-yl)-hydrazinocarbonyl]-cyclobutylmethyl}-N-hydroxy-formamide

Participants

Reaction Steps

To a solution of N-benzyloxy-N-{3-butyl-1-[N′-(4-trifluoromethyl-pyrimidin-2-yl)-hydrazinocarbonyl]-cyclobutylmethyl}-formamide (0.07 g, 0.15 mmol) in methanol (10 mL) was added 10% Pd/C (0.02 g). The reaction mixture was subjected to hydrogenation for 4 h at room temperature. The reaction mixture was then filtered through a pad of Celite@, and washed with methanol (20 mL). Removal of the solvent provided the title compound as a beige solid (0.042 g, 73%). MH+390.

Provenance & Evidence