HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N1-(4-nitrobenzyl)-N4-phenacyl piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Chloroacetophenone | HCID 10757 | — |
| Reactant | 1-(4-Nitrobenzyl)piperazine dihydrochloride | HCID 18005679 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | N1-(4-nitrobenzyl)-N4-phenacyl piperazine dihydrochloride | HCID 86606197 | 59.51% |
Reaction Steps
A mixture of N-(4-nitrobenzyl)piperazine dihydrochloride (7.73 g, 30 mmol), triethylamine (8.37 ml, 60 mmol) and 2-chloro-1-phenylethanone (6.12 g, 39 mmol) in 100 ml of benzene was refluxed for 5 hours, and then treated according to general preparation 2 to give 5.2 g of compound (IV-4), yield 59.51%, mp 236-238° C. M+ 339.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07332495B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-3e33b0424ad041a4aa8e3eae9ec5f55f |
| Source note | uspto-grants-2008_02 |