HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroacetophenone → 1-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroacetophenone | HCID 10757 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Piperazinecarboxaldehyde | HCID 82191 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2) | HCID 23080512 | 95% |
Reaction Steps
A mixture of N-formyl piperazine 35.5 g (310 mmol), 2-chloro-1-phenylethanone (57.6 g, 372 mmol) and anhydrous K2CO3 (64.3 g, 465 mmol) in 320 ml of acetone was treated according to general preparation 1 to give 49 g of N-phenacyl piperazine dihydrochloride, yield 57%, mp 246-8° C. (dec). M+ 204.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07332495B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-728ed3dc421d407489c360614490d115 |
| Source note | uspto-grants-2008_02 |