Potassium Carbonate → N1-(4-nitrobenzyl)-N4-(1-benzoylethyl)piperazine dihydrochloride

HRID 2055221Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2055221
[ClH:1].Cl.[N+:3]([C:6]1[CH:18]=[CH:17][C:9]([CH2:10][N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[CH:8][CH:7]=1)([O-:5])=[O:4].Br[CH:20]([CH3:29])[C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:22].C([O-])([O-])=O.[K+].[K+]>>[ClH:1].[ClH:1].[N+:3]([C:6]1[CH:18]=[CH:17][C:9]([CH2:10][N:11]2[CH2:16][CH2:15][N:14]([CH:20]([C:21](=[O:22])[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH3:29])[CH2:13][CH2:12]2)=[CH:8][CH:7]=1)([O-:5])=[O:4]

Komponenten

4

Edukt 3

HCID 11430Potassium CarbonateHCID 164522-BromopropiophenoneHCID 180056791-(4-Nitrobenzyl)piperazine dihydrochloride

Produkt 1

HCID 69203489N1-(4-nitrobenzyl)-N4-(1-benzoylethyl)piperazine dihydrochlorideAusbeute 1.516,1 %

Versuchsvorschrift

A mixture of N-(4-nitrobenzyl)piperazine dihydrochloride (7.73 g, 26.3 mmol), 2-bromo-1-phenylpropan-1-one (5.94 ml, 39 mmol) and K2CO3 (12.7 g, 92 mol) was treated according to general preparation 2, then recrystallized with ethanol to give 85 g of N1-(4-nitrobenzyl)-N4-(1-benzoylethyl)piperazine dihydrochloride, yield 70%, mp 256-8° C., which was reduced by reductive iron in the similar procedure of Example 12, to give compound (IV-13), yield 65%, mp 244-246° C. (dec). M+ 323.

Aufarbeitung

  1. additionwas treated
  2. customaccording to general preparation 2
  3. customrecrystallized with ethanol

Quellen und Nachweise

ORD-Eintrag
ord-5584b3dd058a416c8104fb602c3cf57a
Quelldatensatz
uspto-grants-2008_02
Patentnummer
US07332495B2

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