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HRID2055231

反应详情

EQUATION

反应方程式

HRID 2055231 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：COc1ccc2cc(C(=O)C(C)Br)ccc2c1Cl
HCID13699429

2-Bromo-1-(5-chloro-6-methoxy-2-naphthalenyl)-1-propanone

C14H12BrClO2

结构：Cl.Cl.O=[N+]([O-])c1ccc(CN2CCNCC2)cc1
HCID18005679

1-[(4-Nitrophenyl)methyl]piperazine--hydrogen chloride (1/2)

C11H17Cl2N3O2

PRODUCTS

生成物

1
结构：COc1ccc2cc(C(=O)C(C)N3CCN(Cc4ccc([N+](=O)[O-])cc4)CC3)ccc2c1Cl.Cl.Cl
HCID69202741

未命名化合物

收率 108.2%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A mixture of N-(4-nitrobenzyl)piperazine dihydrochloride (2.94 g, 10 mmol), 2-bromo-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-one (3.93 g, 12 mmol) and K2CO3 (4.83 g, 35 mmol) in 50 ml of DMF was treated according to general preparation 2 to give 3.51 g of compound (IV-32), yield 65%. M+ 467.

WORKUP

后处理

  1. additionwas treated
  2. customaccording to general preparation 2