Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Hydroxypiperidine | HCID 23293 | — |
| Reactant | 6-chloro-N-(3-chloro-4-methoxyphenyl)-N'-cycloheptyl-[1,3,5]triazine-2,4-diamine | HCID 21897021 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 21897105 | HCID 21897105 | — |
Reaction Steps
A mixture of 3-hydroxypiperidine (0.198 g, 1.96 mmol) and sodium hydroxide (79 mg, 1.96 mmol) in benzene (10 mL) was heated to reflux for 2 hours with stirring under nitrogen atmosphere and then cooled to 25° C. followed by the addition of compound 133 (0.25 g, 0.65 mmol) at same temperature. The mixture was heated to reflux for 6 hours, concentrated under vacuum and diluted with water (10 mL). The precipitated solid was filtered off and purified by column chromatography (1-2% MeOH—CHCl3) to afford the title compound E23 as an off-white solid (0.06 g, 21%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07332488B2 |
|---|
| Source dataset | uspto-grants-2008_02 |
|---|
| ORD ID | ord-6190b69503b649a3bf72b8dd55939bcd |
|---|
| Source note | uspto-grants-2008_02 |
|---|
