HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(Pyridin-4-yl)propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2-Acetamidodibenzothiophene | HCID 108627 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(Pyridin-4-yl)propanoic acid | HCID 233243 | — |
Reaction Steps
To a solution of ethyl 3-pyridin-4-ylpropanoate (Method 2; 103.1 g, 576 mnaol) in water (400 ml) and ethanol (20 ml) at room temperature was added potassium hydroxide (60 g, 1600 mmol). After 18 hours hydrochloric acid (100 ml) was added to give a white solid. Yield 62.8 g (73%). NMR 8.38 (d, 2H), 7.21 (d, 2H), 2.70 (t, 2H), 2.52 (t, 2H); m/z 152.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07332492B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-82f2f0d528194f709d6abe2a07e30874 |
| Source note | uspto-grants-2008_02 |