反应详情

To a solution of ethyl 3-methyl-3-pyridin-4-ylprop-2-enoate (Method 9; 8.4 g, 44 mmol) in ethanol (150 ml) was added 5% palladium on charcoal. The mixture was stirred under an atmosphere of hydrogen for 18 hours. The mixture was filtered through diatomaceous earth and the filtrate evaporated to leave a colourless oil. The crude product was purified by chromatography eluting with 30-50% EtOAc in hexane to give the product as a colourless oil. M/z 194.

1. filtrationThe mixture was filtered through diatomaceous earth
2. customthe filtrate evaporated
3. customto leave a colourless oil
4. customThe crude product was purified by chromatography
5. washeluting with 30-50% EtOAc in hexane