Methanol → 1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-one

HRID 205541Notes

Reaction equation

[CH3:28][OH:29].[F:1][c:2]1[cH:3][cH:4][c:5]([O:20][CH3:21])[c:6]([C:8]([CH2:9][C:10]([CH2:11][OH:12])([OH:13])[C:14]([F:15])([F:16])[F:17])([CH3:18])[CH3:19])[cH:7]1.[I+3:22]([O-:23])([O-:24])([O-:25])[O-:26].[Na+:27]>>[F:1][c:2]1[cH:3][cH:4][c:5]([O:20][CH3:21])[c:6]([C:8]([CH2:9][C:10](=[O:13])[C:14]([F:15])([F:16])[F:17])([CH3:18])[CH3:19])[cH:7]1

Participants

Reactant 4

HCID 887Methanol

HCID 923Sodium ion

HCID 167232Periodate

HCID 219489282-Hydroxy-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-trifluoromethyl-pentanol

Product 1

HCID 100849201,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-one

Sources & evidence

ORD record: ord-e9e8d9d3e9614ac393b1c98ca566f81e
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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