HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-3-chlorobenzoic acid → 1-Benzyl-4-piperidone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-3-chlorobenzoic acid | HCID 33123 | — |
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | HCID 69016183 | HCID 69016183 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 1-Benzyl-4-piperidone | HCID 19220 | — |
Reaction Steps
Following the general procedure described in J. Org. Chem. 1976, 41, 2628, from 2-bromo-3-chloro-benzoic acid (the preparation of which is described in J. Org. Chem. 203, 68, 2030) and 1-benzyl-piperidin-4-one was prepared 7-chloro-3H-spiro[2-benzofuran-1,4′-piperidin]-3-one, after debenzylation (Pd/C, H2, MeOH/HCl), as a white solid. ES-MS m/e (%): 238.7 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07332501B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-9f82cc8f794f416aac514abd40fa1ce3 |
| Source note | uspto-grants-2008_02 |