HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonic acid pyridin-2-ylmethyl ester → 1'-[{6-Chloro-1-(pyridin-2-ylmethyl)-1H-indol-3-yl]carbonyl}-1,2-dihydrospiro[indole-3,4'-piperidine]
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonic acid pyridin-2-ylmethyl ester | HCID 22417657 | — |
| Reactant | 1'-[(6-chloro-1H-indol-3-yl)carbonyl]-1,2-dihydrospiro[indole-3,4'-piperidine] | HCID 59657691 | — |
| Product | 1'-[{6-Chloro-1-(pyridin-2-ylmethyl)-1H-indol-3-yl]carbonyl}-1,2-dihydrospiro[indole-3,4'-piperidine] | HCID 59657607 | — |
Reaction Steps
Following the general procedure III as described above, the alkylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-1,2-dihydrospiro[indole-3,4′-piperidine] (prepared according to example 8) with methanesulfonic acid pyridin-2-ylmethyl ester (described in WO 9955318) gave the title compound. ES-MS m/e (%): 457.2(M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07332501B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-0fa107559e854889a90dd4e8a4564c4c |
| Source note | uspto-grants-2008_02 |