5-Bromo-3H-spiro[isobenzofuran-1,4'-piperidin]-3-one → 1'-[(1-Benzyl-2-methyl-1H-indol-3-yl)carbonyl]-5-bromo-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

HRID 2055454Notes

Reaction equation

HRID 2055454 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3([O:14][C:15](=[O:16])[C:4]=2[CH:3]=1)[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]3.[CH2:17]([N:24]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:26]([C:33](O)=[O:34])=[C:25]1[CH3:36])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:17]([N:24]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:26]([C:33]([N:11]2[CH2:10][CH2:9][C:8]3([C:5]4[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][C:4]=4[C:15](=[O:16])[O:14]3)[CH2:13][CH2:12]2)=[O:34])=[C:25]1[CH3:36])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 533387005-Bromo-3H-spiro[isobenzofuran-1,4'-piperidin]-3-oneHCID 667434811-Benzyl-2-methyl-1H-indole-3-carboxylic acid

Product 1

HCID 596575361'-[(1-Benzyl-2-methyl-1H-indol-3-yl)carbonyl]-5-bromo-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

Procedure

Following the general procedure I as described above, the acylation of 5-bromo-3H-spiro[2-benzofuran-1,4′-piperidin]-3-one with 1-benzyl-2-methyl-1H-indole-3-carboxylic acid (preparation described in example 1), gave the title compound.

Sources & evidence

ORD record
ord-352818c8c04e428aa7d162d9e345d40d
Source dataset
uspto-grants-2008_02
Patent number
US07332501B2

Reaction notes

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