HRID2055481

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734315

3-Biphenylboronic acid

C12H11BO2

结构：O=C1OC2(CCN(C(=O)c3c[nH]c4cc(Cl)ccc34)CC2)c2ccccc21

HCID59657599

未命名化合物

PRODUCTS

生成物

结构：O=C1OC2(CCN(C(=O)c3cn(-c4cccc(-c5ccccc5)c4)c4cc(Cl)ccc34)CC2)c2ccccc21

HCID59657717

未命名化合物

PROCEDURE

实验过程

Following the general procedure VI as described above, the arylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4′-piperidin]-3-one (prepared according to example 16) with commercially available 3-biphenylboronic acid gave the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ad5d1d2733fe45d7b5699d4f484fcb56
来源数据集: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07332501B2
来源说明: uspto-grants-2008_02

反应 SMILES

[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][C:16]4([C:22]5[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=5[C:20](=[O:27])[O:19]4)[CH2:15][CH2:14]3)=[O:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[C:28]1([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[CH:33]=[CH:32][CH:31]=[C:30](B(O)O)[CH:29]=1>>[C:28]1([C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH:33]=[CH:32][CH:31]=[C:30]([N:8]2[C:9]3[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:10]=3)[C:6]([C:11]([N:13]3[CH2:18][CH2:17][C:16]4([C:22]5[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=5[C:20](=[O:27])[O:19]4)[CH2:15][CH2:14]3)=[O:12])=[CH:7]2)[CH:29]=1