HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-5-(chloromethyl)-2-methylpyrimidine → 1'-({1-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-6-chloro-1H-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-5-(chloromethyl)-2-methylpyrimidine | HCID 421245 | — |
| Reactant | 1'-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one | HCID 59657623 | — |
| Product | 1'-({1-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-6-chloro-1H-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one | HCID 59657673 | — |
Reaction Steps
Following the general procedure III as described above, the alkylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4′-piperidin]-3-one (prepared according to example 19 above) with 5-chloromethyl-2-methyl-pyrimidin-4-ylamine (described in Pharmaceutical Chemistry Journal (Translation of Khimiko-Farmatsevticheskii Zhurnal) (1999), 33(2), 101-103) gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07332501B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-be63d223d32f4440971b02e263b47767 |
| Source note | uspto-grants-2008_02 |