HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetamidomalonic acid diethyl ester → HCID 69016854, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetamidomalonic acid diethyl ester | HCID 14041 | — |
| Reactant | Cyclopropanecarbonyl chloride | HCID 77637 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 69016854 | HCID 69016854 | 60% |
Reaction Steps
To a solution of 6 eq KOt-Bu in THF at room temperature was added 6 eq 2-acetylamino-malonic acid diethyl ester and after 5 min 1 eq cyclopropane-carbonylchloride. After 15 min, the mixture was concentrated and partitioned between EtOAc and H2O. The organic layer was concentrated to give the desired product in 60% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07332501B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-35457208be5645d799829e4ff1faa145 |
| Source note | uspto-grants-2008_02 |