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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2055527Generated: November 2, 2026

1,4-Dibenzyl-2-(chloromethyl)piperazine → HCID 59657554, compound

https://huagongshe.com/reaction/2055527

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dibenzyl-2-(chloromethyl)piperazineHCID 10663119—
Reactant(6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanoneHCID 15951937—
ProductHCID 59657554HCID 59657554—

Reaction Steps

Following the general procedure III as described above, the alkylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4′-piperidine] (prepared according to example 69 above) with 1,4-dibenzyl-2-chloromethyl-piperazine (described in Journal of Medicinal Chemistry (1999), 42(9), 1587-1603) gave the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07332501B2
Source datasetuspto-grants-2008_02
ORD IDord-a51c45e05ac14d8b941211a661e19ef9
Source noteuspto-grants-2008_02