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(6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone → 1'-{[6-Chloro-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-1,4'-piperidine]
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone | HCID 15951937 | — |
| 反応物 | 2-(Tetrahydro-2H-pyran-4-yl)ethyl methanesulfonate | HCID 22273083 | — |
| 生成物 | 1'-{[6-Chloro-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-1,4'-piperidine] | HCID 59657638 | 55% |
反応手順
Following the general procedure III as described above, the alkylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4′-piperidine] (prepared according to example 69) with commercially available methanesulfonic acid 2-(tetrahydro-pyran-4-yl)-ethylester (described in US 2004220214) gave the title compound in 55% yield. ES-MS m/e (%): 465.2(M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07332501B2 |
| 出典データセット | uspto-grants-2008_02 |
| ORD ID | ord-b763e2bdd99440cc80c53e1b8b08612b |
| 出典メモ | uspto-grants-2008_02 |