3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole → HCID 11417818, compound

HRID 2055572Notes

Reaction equation

HRID 2055572 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:14](=[O:15])[N:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]2=[N:7]1.[NH:16]1[CH2:21][CH:20]=[C:19]([C:22]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[NH:24][CH:23]=2)[CH2:18][CH2:17]1>>[NH:24]1[C:25]2[C:30](=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:22]([C:19]2[CH2:20][CH2:21][N:16]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]3[C:14](=[O:15])[N:9]4[CH:10]=[CH:11][CH:12]=[CH:13][C:8]4=[N:7]3)[CH2:17][CH:18]=2)=[CH:23]1

Participants

3

Reactant 2

HCID 27610233-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indoleHCID 22326634HCID 22326634, compound

Product 1

HCID 11417818HCID 11417818, compound

Procedure

2-{4-[4-(1H-Indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-butyl}-2H-[1,2,4]triazolo[4,3-a]pyridin-3-one was prepared by reacting 2-(4-Chloro-butyl)-2H-[1,2,4]triazolo[4,3-a]pyridin-3-one (225 mg, 1 mmol) and 3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1H-indole (198 mg, 1 mmol) by adopting the procedure as outlined in Experimental 24. Yield: 87 mg (22%) compound was isolated as pale yellow solid. Mp: 123.2° C.; M+388.1

Sources & evidence

ORD record
ord-12664cd848ab44f9989c32231388ae90
Source dataset
uspto-grants-2008_02
Patent number
US07332506B2

Reaction notes

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