HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → Ethyl 1-[(pyrimidin-5-ylcarbonyl)amino]-cyclopropanecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Pyrimidine-5-carboxylic acid | HCID 78346 | — |
| Reactant | HOAt | HCID 181649 | — |
| Reactant | (1-Ethoxycarbonylcyclopropyl)azanium chloride | HCID 91658617 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 1-[(pyrimidin-5-ylcarbonyl)amino]-cyclopropanecarboxylate | HCID 67444517 | — |
Reaction Steps
Triethylamine (7.026 g, 69.44 mmol) was added to a suspension of 1-(ethoxycarbonyl)cyclopropanaminium chloride (11.50 g, 69.44 mmol), pyrimidine-5-carboxylic acid (8.617 g, 69.44 mmol), EDC (13.312 g, 69.44 mmol), and HOAT (0.945 g, 69.44 mmol) in CH2Cl2 (125 mL) and allowed to stir for 16 hours. The reaction was adsorbed onto silica and purified by silica gel chromatography and eluted with ethyl acetate to yield ethyl 1-[(pyrimidin-5-ylcarbonyl)amino]-cyclopropanecarboxylate as a white solid. Low resolution mass spectrometry: (M+H+)=236.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07332499B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-cad218f086cc47138a4301be644bec99 |
| Source note | uspto-grants-2008_02 |