1,2-Dichloroethane → HCID 86608818, compound

Participants

Reaction Steps

(1R)-1-(4-Bromo-2-fluorophenyl)ethanaminium chloride (16.50 g, 64.83 mmol), 1-[(trifluoroacetyl)amino]cyclopropanecarboxylic acid (12.78 g, 64.83 mmol), EDC (12.43 g, 64.83 mmol), and HOAT (4.41 g, 32.41 mmol) were dissolved in dimethylformamide (100 mL). To this solution was added triethylamine (6.56 g, 64.83 mmol). After 6 hours, the reaction was diluted with water and extracted with ethyl acetate. The organic extract was washed with water, dried over sodium sulfate, filtered and concentrated under reduced pressure to yield a solid. This solid was purified by silica gel chromatography and eluted with 5% methanol/CH2Cl2 to yield N-[(1R)-1-(4-bromo-2-fluorophenyl)ethyl]-1-[(trifluoroacetyl)amino]cyclopropanecarboxamide as a white solid. Low resolution mass spectrometry: (M+H+)=399.0.

Provenance & Evidence