Sodium Hydroxide → HCID 69267825, compound

Participants

Reaction Steps

To a solution of N-[(1R)-1-(2′-amino-3,3′-difluoro-1,1′-biphenyl-4-yl)ethyl]-1-[(trifluoroacetyl)amino]cyclopropanecarboxamide (174 mg 0.407 mmol) in methanol (2 ml) was added 1.0N NaOH (2 ml, 2 mmol) and stirred at room temperature 4 days. This mixture was concentrated under vacuum to a 2 ml volume and extracted with methylene chloride (2×10 ml). The combined extracts were washed with water (1 ml), dried over MgSO4, filtered and the solvent removed in vacuo to give 1-amino-N-[(1R)-1-(2′-amino-3,3′-difluoro-1,1′-biphenyl-4-yl)ethyl]cyclopropanecarboxamide. Low resolution mass spectrometry: (M+H+)=332.3.

Provenance & Evidence