HuagongsheHuagongshe Chemistry Print Report · For research reference only
Serinol → HCID 12090256, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Serinol | HCID 68294 | — |
| Reactant | 3-Pyridinecarboxylic acid, 4-(trifluoromethyl)- | HCID 2777549 | — |
| Reactant | Bis-(1H-imidazol-2-YL)-methanone | HCID 5250894 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 12090256 | HCID 12090256 | — |
Reaction Steps
3.9 g (20 mmol) of 4-trifluoromethylnicotinic acid and 3.2 g (20 mmol) of carbonyl diimidazole in 100 ml of dry tetrahydrofuran were stirred at 40-50° C. for 6 hours. After cooling, 1.8 g (20 mmol) of serinol were added, and stirring was continued at 50-60° C. for another 4 hours. The crude product obtained after removal of the solvent under reduced pressure was purified by silica gel chromatography. This gave 2.9 g of product (55.3% of theory) of melting point 155-156° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07332509B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-0775abb15be34616883792a81fc56a43 |
| Source note | uspto-grants-2008_02 |