[1-(4-fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol → 1-(4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde

HRID 2055596Notes

Reaction equation

HRID 2055596 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([CH2:13][OH:14])[N:10]=[C:9]2[CH3:15])=[CH:4][CH:3]=1>C(Cl)Cl.[Mn]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([CH:13]=[O:14])[N:10]=[C:9]2[CH3:15])=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 67303957[1-(4-fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol

Product 1

HCID 859979931-(4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde

Reagents, catalysts & solvents 2

HCID 23930ManganeseCatalystHCID 6344DichloromethaneSolvent

Procedure

[1-(4-Fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol is dissolved in methylene chloride. Mangan (IV) oxide is added and the reaction mixture is stirred at room temperature for 3 days. The suspension is filtered through a dicalite speed plus pad and the desired compound (4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde is obtained.

Workup

  1. filtrationThe suspension is filtered through a dicalite speed plus pad

Sources & evidence

ORD record
ord-614d1eb1681049ba809ddc3672563b26
Source dataset
uspto-grants-2008_02
Patent number
US07332510B2

Reaction notes

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