反应详情

温度

55 °C

3-{4-[(Hydroxyamino)(imino)methyl]phenoxy}-5-[(1S)-2-methoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide was taken up in trimethyl orthoformate (3 mL) and 2 drops of borontrifluoroetherate added. The resulting solution was heated to 55° C. in a CEM explorer microwave for 80 mins. The volatiles were removed under reduced pressure and the resulting oil chromatographed on silica, eluting with 0-100% ethyl acetate in iso-hexane, to give the desired compound as a white foam (295 mg)

1. addition2 drops of borontrifluoroetherate added
2. customThe volatiles were removed under reduced pressure
3. customthe resulting oil chromatographed on silica
4. washeluting with 0-100% ethyl acetate in iso-hexane