Dimethylformamide → HCID 9805331, compound

Participants

Reaction Steps

Preparation of Formula 106 where R1 to R3 are H; R5 is Benzyl; R6 is i-Propyl; R6′ is H; W, X and Y are —C═; and Z is —N═: A mixture of 3-benzyl-2-(1-bromo-2-methyl-propyl)-3-H-pyrido[2,3-d]pyrimidin-4-one (9.603 mmol), NaN3 (1.25 g, 19.206 mmol) and DMF (25 mL) was stirred at 60 C overnight and concentrated under the reduced pressure. The residue was dissolved in dichloromethane, washed with water and brine, dried (Na2SO4) and concentrated. The desired product, 2-(1-azido-2-methyl-propyl)-3-benzyl-3-H-pyrido[2,3-d]pyrimidin-4-one, was obtained as a syrup which was taken on without further purification.

Provenance & Evidence