HCID 69315092, compound → HCID 22172631, compound

Participants

Reaction Steps

Formula 107a where R1, R3 and R4 are H; R5 is Benzyl; R6 is Isopropyl; R6′ is H; W, Y and Z are —C═; and X is —N═: [1-(3-Benzyl-4-oxo-3,4-dihydro-pyrido[4,3-d]pyrimidin-2-yl)-2-methyl-propyl]-carbamic acid benzyl ester (0.850 g, 1.92 mmol) was dissolved in a solution of HBr/acetic acid (16 mL, 30% wt) and the mixture stirred for 2 hours at room temperature. The solvents were removed under reduced pressure to give the corresponding de-protected amine of Formula 107a, 2-(1-amino-2-methyl-propyl)-3-benzyl-3H-pyrido[4,3-d]pyrimidin-4-one, as a solid HBr salt, which was taken on without further purification. MS (Cl) M/E: 309.3.

Provenance & Evidence