1,2,3,4-Tetrahydroisoquinoline → HCID 68804900, compound

HRID 2055685Notes

Reaction equation

HRID 2055685 reaction equation
[Cl:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:13][N:12]=[C:11]([CH2:14][CH:15]3[CH2:20][CH2:19][N:18]([CH:21]([CH2:24][CH3:25])[CH2:22][CH3:23])[CH2:17][CH2:16]3)[N:10]=2)=[CH:5][CH:4]=1.[CH2:26]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:29][CH2:28][NH:27]1>>[ClH:1].[ClH:1].[CH2:22]([CH:21]([N:18]1[CH2:19][CH2:20][CH:15]([CH2:14][C:11]2[N:10]=[C:9]([C:6]3[CH:7]=[CH:8][C:3]([CH2:2][N:27]4[CH2:28][CH2:29][C:30]5[C:35](=[CH:34][CH:33]=[CH:32][CH:31]=5)[CH2:26]4)=[CH:4][CH:5]=3)[O:13][N:12]=2)[CH2:16][CH2:17]1)[CH2:24][CH3:25])[CH3:23]

Participants

3

Reactant 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 59657777HCID 59657777, compound

Product 1

HCID 68804900HCID 68804900, compound

Procedure

The title compound was prepared by a similar procedure to that described in Example 23, starting from 4-[5-(4-(chloromethyl)phenyl)[1,2,4]oxadiazol-3-ylmethyl]-1-(1-ethylpropyl)piperidine and 1,2,3,4-tetrahydroisoquinoline.

Sources & evidence

ORD record
ord-de39f787c8aa43d6ac0c7bd5e0f8985e
Source dataset
uspto-grants-2008_02
Patent number
US07332508B2

Reaction notes

Loading…