4-Ethylbenzoyl chloride → 1-Isopropyl-4-[5-(4-ethylphenyl)[1,2,4]oxadiazol-3-yl]piperidine, Hydrochloride

HRID 2055708Notes

Reaction equation

HRID 2055708 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]([NH:12][OH:13])=[NH:11])[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[CH2:14]([C:16]1[CH:24]=[CH:23][C:19]([C:20]([Cl:22])=O)=[CH:18][CH:17]=1)[CH3:15]>>[ClH:22].[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[N:11]=[C:20]([C:19]3[CH:23]=[CH:24][C:16]([CH2:14][CH3:15])=[CH:17][CH:18]=3)[O:13][N:12]=2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 853684-Ethylbenzoyl chlorideHCID 178456252HCID 178456252, compound

Product 1

HCID 688058951-Isopropyl-4-[5-(4-ethylphenyl)[1,2,4]oxadiazol-3-yl]piperidine, Hydrochloride

Procedure

The title compound was prepared by a similar procedure to that described in Example 56, starting from 1-isopropyl-N-hydroxypiperidine-4-carboxamidine and 4-ethylbenzoyl chloride.

Sources & evidence

ORD record
ord-cba972a7c9544c49ad6868f51cb5156e
Source dataset
uspto-grants-2008_02
Patent number
US07332508B2

Reaction notes

Loading…