HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ibuprofen, (+-)- → 2-(4-Isobutyl-phenyl)-N-[4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ibuprofen, (+-)- | HCID 3672 | — |
| Reactant | 4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-ylamine | HCID 11557499 | — |
| Product | 2-(4-Isobutyl-phenyl)-N-[4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-propionamide | HCID 18440832 | 63% |
Reaction Steps
Pet-152 was prepared according to the general procedure described hereinabove and the procedure described above for the preparation of Pet-154, using 2-(4-isobutyl-phenyl)-propionic acid (Ibuprofen) and 4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-ylamine (Pet-10) as the starting materials, in an overall yield of 63%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07332513B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-41d6f60d753149d081c932cabba73f11 |
| Source note | uspto-grants-2008_02 |