Triethylamine → HCID 86600443, compound

Participants

Reaction Conditions

Reaction Steps

Azidophosphoric acid diphenyl ester (15.4 g; 56 mmole) and triethylamine (5.66 g; 55 mmole) were added to 8-thiophen-3-yl-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid (15 g; 56 mmole) dissolved in anisole (160 ml). The reaction mixture was heated for 2 hours to 90 to 100° C. On completion of the reaction (reaction monitored by thin layer chromatography), the mixture was purified by column chromatography (silica gel, 10% ethyl acetate in n-hexane). 6 g of 8-isocyanato-8-thiophen-3-yl-1,4-dioxa-spiro[4.5]decane were obtained (41%; colorless liquid).

Provenance & Evidence