2-(1-Ethoxycarbonyl-2-vinylcyclopropylcarbamoyl)-4-hydroxycyclopentanecarboxylic acid tert-butyl ester → 2-(1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-[2-(3,5-difluoro-phenyl)-7-methoxy-8-methyl-quinazolin-4-yloxy]-cyclopentanecarboxylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[CH:8]1[CH:9]([C:14]([NH:15][C:16]2([C:21](=[O:22])[O:23][CH2:24][CH3:25])[CH:17]([CH:19]=[CH2:20])[CH2:18]2)=[O:26])[CH2:10][CH:11]([OH:13])[CH2:12]1.[F:27][c:28]1[cH:29][c:30](-[c:35]2[n:36][c:37]3[c:38]([CH3:48])[c:39]([O:46][CH3:47])[cH:40][cH:41][c:42]3[c:43]([OH:45])[n:44]2)[cH:31][c:32]([F:34])[cH:33]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[CH:8]1[CH:9]([C:14]([NH:15][C:16]2([C:21](=[O:22])[O:23][CH2:24][CH3:25])[CH:17]([CH:19]=[CH2:20])[CH2:18]2)=[O:26])[CH2:10][CH:11]([O:13][c:43]2[c:42]3[c:37]([n:36][c:35](-[c:30]4[cH:29][c:28]([F:27])[cH:33][c:32]([F:34])[cH:31]4)[n:44]2)[c:38]([CH3:48])[c:39]([O:46][CH3:47])[cH:40][cH:41]3)[CH2:12]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-62ab3a157c9040899a475f7a79fcdd41
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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