反应详情

温度

50 °C

To a solution of 6-chloro-3-phenyl-4-(4-trifluoromethyl-phenyl)-pyridazine, (Example 13 (e)), (106 mg, 0.3 mmol) and 7-hydroxyquinoline (55 mg, 0.4 mmol, Acros) in DMF (2.5 mL) was added NaH (22 mg, 0.6 mmol, 60% suspension in mineral oil, Aldrich) and the mixture was stired at room temperature for 15 h. The reaction mixture was then heated at 50° C. for another 28 h, allowed to cool to room temperature and the solvent removed in vacuum. The residue was partitioned between EtOAc/H2O and the aqueous layer was extracted with EtOAc. The combined organic layers were evaporated onto SiO2 and purified by flash silica gel chromatography with EtOAc/hexanes (0:1→3:7) as eluant to give the title 15 compound as an off-white amorphous solid. Mp: 178-183° C. MS (ESI, pos ion.) m/z: 444 (M+1).

1. temperatureto cool to room temperature
2. customthe solvent removed in vacuum
3. customThe residue was partitioned between EtOAc/H2O
4. extractionthe aqueous layer was extracted with EtOAc
5. customThe combined organic layers were evaporated onto SiO2
6. custompurified by flash silica gel chromatography with EtOAc/hexanes (0:1→3:7) as eluant
7. customto give the title 15 compound as an off-white amorphous solid