4-Isoquinolinol → HCID 10316875, compound

HRID 2055990Notes

Reaction equation

HRID 2055990 reaction equation
F[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:5]=[CH:4][N:3]=1.[CH:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:21]([OH:28])=[CH:20][N:19]=1>>[F:15][C:14]([F:17])([F:16])[C:11]1[CH:12]=[CH:13][C:8]([C:6]2[N:5]=[CH:4][N:3]=[C:2]([O:28][C:21]3[C:22]4[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH:18]=[N:19][CH:20]=3)[CH:7]=2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 187504-IsoquinolinolHCID 16748337HCID 16748337, compound

Product 1

HCID 10316875HCID 10316875, compound

Procedure

The title compound was prepared from 4-fluoro-6-(4-trifluoromethyl-phenyl)-pyrimidine (Example 169(a) and isoquinolin-4-ol (MonomerChem) analogous to the conditions described in Example 169(b). Mp: 206-211° C. MS (ESI, pos. ion) m/z: 368.2 (M+1).

Sources & evidence

ORD record
ord-a19da4bd2e0140adb39efbe3bf5c592e
Source dataset
uspto-grants-2008_02
Patent number
US07332511B2

Reaction notes

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