HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexanemethylamine → HCID 21865077, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexanemethylamine | HCID 76688 | — |
| Reactant | HCID 21865127 | HCID 21865127 | — |
| Product | HCID 21865077 | HCID 21865077 | — |
Reaction Steps
According to the procedure described in Example 188, 7-[6-(2-chloro-6-trifluoromethyl-pyridin-3-yl)-pyrimidin-4-yloxy]-quinoline (Example 187) (110 mg, 0.27 mmol) and cyclohexanemethylamine (43 pL, 0.33 mmol, Aldrich), after purification by silica gel chromatography (gradient, 0 to 3% MeOH/CH2Cl2) and then preparative TLC (4% MeOH/CH2Cl2), provided the title compound as a yellow solid. MP: 151-152° C. MS (ESI, pos. ion) m/z: 480 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07332511B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-4d4007b65892455b95a1d624b5036b99 |
| Source note | uspto-grants-2008_02 |