Phosphine oxide, (chloromethyl)dimethyl- → [1-(7-Ethyl-3-methylxanthin-1-yl)methyl]dimethylphosphine Oxide

HRID 2056Notes

Reaction equation

HRID 2056 reaction equation
[CH2:1]([N:3]1[C:11]2[C:10](=[O:12])[NH:9][C:8](=[O:13])[N:7]([CH3:14])[C:6]=2[N:5]=[CH:4]1)[CH3:2].Cl[CH2:16][P:17](=[O:20])([CH3:19])[CH3:18]>>[CH2:1]([N:3]1[C:11]2[C:10](=[O:12])[N:9]([CH2:16][P:17](=[O:20])([CH3:19])[CH3:18])[C:8](=[O:13])[N:7]([CH3:14])[C:6]=2[N:5]=[CH:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 74224Phosphine oxide, (chloromethyl)dimethyl-HCID 3507197-Ethyl-3-methyl-1,3,7-trihydropurine-2,6-dione

Product 1

HCID 19689257[1-(7-Ethyl-3-methylxanthin-1-yl)methyl]dimethylphosphine Oxide

Procedure

The title substance was prepared from 5 g (0.0258 mol) of 7-ethyl-3-methylxanthine and 3.91 g (0.031 mol) of chloromethyl-dimethylphosphine oxide analogously to Example 67.

Sources & evidence

ORD record
ord-02b576534acf4dda8bd059063a4bc1e5
Source dataset
uspto-grants-1998_03
Patent number
US05728686

Reaction notes

Loading…