反应详情

Following the procedure of Example 1b), except substituting 2-methoxy-5-chlorophenylboronic acid; for 4-carboxyphenylboronic acid;, and substituting 5-(3-bromophenyl)-1H-tetrazole for the compound of 1a), the title compound was prepared (1.36 g; 100%) as a white solid. 1H NMR (300 MHz, d6-DMSO) δ 8.16(s, 1H), 8.05(d, J=7.6 Hz, 1H), 7.7(d, J=6.6 Hz, 1H), 7.67(t, J=7.7 Hz, 1H), 7.48(m, 2H), 7.2(d, J=9.1 Hz, 1H), 3.8(s, 3H), MS(ES) m/z 287 [M+H]. b) 5-(5′-chloro-2′-hydroxybiphenyl-3-yl)-1H-tetrazole