Bromocyclopentane → HCID 9995649, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-(1-butyl)-2-trifluoromethylpurine (35 mg, 0.14 mmol), bromocyclopentane (89 mg, 0.60 mmol), potassium carbonate (83 mg, 0.6 mmol) and N,N-dimethylformamide (3 ml) was heated to 100° C. After 8 hours, the reaction mixture was cooled to 40° C. and concentrated under vacuum. The residue was treated with 15 ml of ethyl acetate and washed with 5% sodium bicarbonate (2×15 mL). The organic layer was concentrated and purified by chromatography (20% ethyl acetate in hexane) to give 6-(1-butyl)-9-cyclopentyl-2-trifluoromethylpurine (26.6 mg, 60% yield).

Provenance & Evidence