HCID 11287642, compound → HCID 11148145, compound

HRID 2056266Notes

Reaction equation

HRID 2056266 reaction equation
C[O:2][C:3]([C:5]1[O:9][N:8]=[C:7]([O:10][CH2:11][C:12]([O:14]CC)=[O:13])[CH:6]=1)=[O:4]>CO.[OH-].[Na+]>[C:3]([C:5]1[O:9][N:8]=[C:7]([O:10][CH2:11][C:12]([OH:14])=[O:13])[CH:6]=1)([OH:4])=[O:2]

Participants

4

Reactant 1

HCID 11287642HCID 11287642, compound

Product 1

HCID 11148145HCID 11148145, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A solution of ethyl (5-(methoxycarbonyl)isoxazol-3-yl)oxyacetate (4 mmol, Example 73) in methanol (60 mL) and 5% aqueous NaOH is heated at reflux for 1 hour. At the end of this time, the methanol is removed, the residue diluted with additional water, and acidified to pH=4 with hydrochloric acid. The resulting precipitate is collected by filtration, washed with cold water, and dried.

Workup

  1. temperatureat reflux for 1 hour
  2. customAt the end of this time, the methanol is removed
  3. additionthe residue diluted with additional water
  4. filtrationThe resulting precipitate is collected by filtration
  5. washwashed with cold water
  6. customdried

Sources & evidence

ORD record
ord-12f1b06ac18f4c0ab03fe67d2a7285d8
Source dataset
uspto-grants-2008_02
Patent number
US07335655B2

Reaction notes

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