HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carbothioic acid [4-(pyrimidin-2-ylsulfamoyl)-phenyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 6,7-Dimethoxy-4-piperazin-1-yl-quinazoline | HCID 2758484 | — |
| Reactant | N-Pyrimidin-2-yl-4-thioformylamino-benzenesulfonamide chloride | HCID 86601004 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carbothioic acid [4-(pyrimidin-2-ylsulfamoyl)-phenyl]-amide | HCID 59020517 | — |
Reaction Steps
To a solution of 4-(1-piperazinyl)-6,7-dimethoxy quinazoline (200 mg, 0.73 mmol) and pyridine (0.5 mL, 6.4 mmol) in dichloromethane (20 mL) was added a solution of product 1d in dichloromethane (20 mL) and this was stirred overnight. Methanol was added to quench excess thiophosgene, and the residue after removal of solvent was purified by silica gel column chromatography eluting with 5% methanol/dichloromethane and further recrystallized from dichloromethane/hexane to give 80 mg (20%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07335662B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-e629606619334f0299cc30342b2ccf3f |
| Source note | uspto-grants-2008_02 |