o-(Trifluoromethyl)benzaldehyde → 4-Iodomethyl-5-ethyl-2-(2-trifluoromethylphenyl)oxazole

HRID 2056392Notes

Reaction equation

HRID 2056392 reaction equation
[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][C:17](C)=[CH:16][CH:15]=2)[O:6][C:7]=1[C:8]1[CH:13]=CC=CC=1.C(C(=O)C(=NO)C)C.[F:29][C:30]([F:40])([F:39])C1C=CC=CC=1C=O>>[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:19]=2[C:30]([F:40])([F:39])[F:29])[O:6][C:7]=1[CH2:8][CH3:13]

Participants

4

Reactant 3

HCID 123067o-(Trifluoromethyl)benzaldehydeHCID 67974532,3-Pentanedione, 2-oximeHCID 574345044-Iodomethyl-5-phenyl-2-p-tolyloxazole

Product 1

HCID 574345094-Iodomethyl-5-ethyl-2-(2-trifluoromethylphenyl)oxazole

Procedure

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyl-oxazole, 1-ethyl-1,2-propanedione-2-oxime and 2-trifluoromethylbenzaldehyde gave 4-iodomethyl-5-ethyl-2-(2-trifluoromethylphenyl)oxazole.

Sources & evidence

ORD record
ord-c666acade1e6425a947ed7a6dec68d75
Source dataset
uspto-grants-2008_02
Patent number
US07335671B2

Reaction notes

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