3-Methoxybenzaldehyde → 4-Iodomethyl-2-(3-methoxyphenyl)-5-methyloxazole

HRID 2056394Notes

Reaction equation

HRID 2056394 reaction equation
[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][C:17](C)=[CH:16][CH:15]=2)[O:6][C:7]=1[C:8]1C=CC=CC=1.C/C(/[C:25](C)=[O:26])=N\O.C(=O)C1C=CC=C(OC)C=1>>[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:26][CH3:25])[CH:15]=2)[O:6][C:7]=1[CH3:8]

Participants

4

Reactant 3

HCID 115693-MethoxybenzaldehydeHCID 64096332,3-Butanedione monoximeHCID 574345044-Iodomethyl-5-phenyl-2-p-tolyloxazole

Product 1

HCID 219803164-Iodomethyl-2-(3-methoxyphenyl)-5-methyloxazole

Procedure

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyl-oxazole, diacetylmonoxime and m-anisaldehyde gave 4-iodomethyl-2-(3-methoxy-phenyl)-5-methyloxazole.

Sources & evidence

ORD record
ord-8a23a1f88e954545bef982fbba8d56a9
Source dataset
uspto-grants-2008_02
Patent number
US07335671B2

Reaction notes

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